Job Description

Job Advert Summary

Guided by its purpose to provide products for patients to alleviate pain and suffering and improve their quality of life, NBI's vision is to be the leading African manufacturer and supplier of quality therapeutic proteins and diagnostic products.



National Bioproducts Institute NPC has a vacancy for the role of Diagnostic Product Production Analyst . The successful incumbent will be required to :



To use as an individual, his/her academic background, training and experience to perform immunoassay, protein expression and purifications prescribed for the production and QC analysis of saleable monoclonal antibodies, recombinant antigens, and MAT kit and components.



Applications are invited from suitably qualified and experienced candidates.

Minimum Requirements

Essential: BSc in Biochemistry, Microbiology Preferred: BSc Honours in Biochemistry, Microbiology 2-3 years ELISA experience and 2-3 years recombinant protein expression and purification experience

Duties and Responsibilities

QC testing of MAT ELISA reagents, components and final kits

QC testing of final MAT kit. Complete documentation for final kit and upload results on SAP Perform test and method validations according to internal DPP program.

Production and QC testing of recombinant antigens associated with saleable monoclonal antibodies and monoclonal antibodies

Express and purify recombinant proteins to support monoclonal antibody production of saleable antibodies. When required, assist with purifications of monoclonal antibodies for hybridoma and mAb validation projects QC testing to validate activity, specificity and coating concentration of produced recombinant antigens.

QC analysis of NBI saleable monoclonal antibodies

Perform QC analysis on purified saleable monoclonal antibodies using sds-page gel electrophoresis and determine the antibody purity by densitometric analysis using gel imaging software. Provide mAb purity and gel result documentation to Section Head: Antibody Production to complete final release of NBI monoclonal antibodies

Execute activities of the Hybridoma laboratory when required

Perform cell culture and injection duties of the Hybridoma Cell Biologist when required Culture specific monoclonal antibodies for research and commercial purposes Interprets and reports results to the Section Head: Antibody Production

Laboratory resourcing and equipment maintenance

Maintain laboratory equipment and cleanliness Maintain chemical and operational consumable stock levels. Ensure compliance with ISO13485 standards. * Perform the general housekeeping of the laboratory.